{"metadata":{"accession":"A4I1W6","id":"A4I1W6_LEIIN","source_organism":{"taxId":"5671","scientificName":"Leishmania infantum","fullName":"Leishmania infantum"},"name":"Cleavage and polyadenylation specificity factor subunit 5","description":["Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs"],"length":271,"sequence":"MSLKAKLDVYPLENYTQTSVDVSNGHAGVAGNKVNLGAGNSAPFRPPSAIEKLLSLKKRCEEEPCVHSVEGVLLVHLHRHPHILLMKQINLRTHDADGMRTVPPSNTNAEATYRLPGGRCRRGEAEESCLLRKLGRHLLNEAKAPAGAAEVASAGNSDTVVDVGMTHNASKAGSCFRVGEVLATWYRPHFTPHMYPYVPAHIAAGSVREVRAIYLVHLEPTVYFSMVQEGVELVAAPLFDLYENASKYGPIIASLPALLSRVLINYCSTEY","proteome":"UP000008153","gene":"LINJ_26_0280","go_terms":[{"identifier":"GO:0003729","name":"mRNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0031124","name":"mRNA 3'-end processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005849","name":"mRNA cleavage factor complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"1abbcd35c1fbc9bb803fc45a3dfc3272dc7bafbb","counters":{"domain_architectures":4834,"entries":5,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":1,"pirsf":1,"panther":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":4834}}}