{"metadata":{"accession":"A1R726","id":"RUVC_PAEAT","source_organism":{"taxId":"290340","scientificName":"Paenarthrobacter aurescens (strain TC1)","fullName":"Paenarthrobacter aurescens (strain TC1)"},"name":"Crossover junction endodeoxyribonuclease RuvC","description":["The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA"],"length":189,"sequence":"MTLRVLGVDPGLTRCGIGVVDIEKNRRATMVAVGVVGTSAELTLDKRLLVIAQAIDEWLDRHEPDVVAVERVFSQMNVSTVMGVAQASGVVIAAAARRGIPVALHTPSEVKAAVTGSGTANKDAVTKLVTKILRLDAPPKPADAADALALALTHAWRAGSGMGAASGNSSLTPAQKAWADAEAKARRKR","proteome":"UP000000637","gene":"ruvC","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004520","name":"DNA endonuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006310","name":"DNA recombination","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008821","name":"crossover junction DNA endonuclease activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d60f1a9bedb8f81580f51119033923af5affee26","counters":{"domain_architectures":22245,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"pfam":1,"cdd":1,"hamap":1,"panther":1,"ncbifam":1,"prosite":1,"prints":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":22245}}}