{"metadata":{"accession":"A1CBC9","id":"DCL1_ASPCL","source_organism":{"taxId":"344612","scientificName":"Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)","fullName":"Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)"},"name":"Dicer-like protein 1","description":["Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity)"],"length":1534,"sequence":"MSSDLISQAESISNIEILRALFITDTHTTVGDVAVPSAEPGVEHDQISPGESDEEIEENISDQNNSSSQKRLQNAQFEALLTRRAEDTSNENIDRVPLNLSDNELSIAHLVAKQDVGGGLLDPREYQIELFERAKAQNTIAVLDTGSGKTLIAVLLLRHVLQNELNDRANGKPHRVSFFLVDSVTLAYQQAAVLRNNIDQNVAHFFGAMGTDLWDRQVWEEHLQQNMVIVCTAEILNQCLLNSHVRMNQINLLIFDEAHHTKKDHPYARIIRDSYFKASPPQRPRIFGMTASPIDTKGDIIAAATRLETLLDSRIATTSKITLLRQVVSRPIEKVWAYDRLESPFKTNLHKLMENRFGNVKALEGVFRFAWYASSELGRWCSDRAWLYALADDVLPKLEGHVNKLAESTAAATERDMAFKEITLIKEASNIVKAHTFNDPEFPGELSPKVRLLQTELSKHFSHAPETKCIIFTQKRYTAKTLHELFTILSIPHLRPGVLIGVRSGDIGGMNITFRQQFLALVKFRKGEINCLFATSVAEEGLDIPDCNLVVRFDLYHTLIQYVQSRGRARHYHSTYASMVEKDNSDHEARLREVREAEKTMQNFCETLPEDRILHGNDHDLDSLLQHEEGRRTFTVKSTGARLTYHSAIAILARYASSLQYEKETTPQATYVVQSVGNTYVCEVILPEKSPIRGLTGSPAIRKSIAKQSAAFDTCLLLRRHKLLDDFFKSIYHKRLPAMRNAKLAITSKKTNQYDMLLKPSIWRRHQGILPSKLYGTILSLLPSEPLSREHQPILVLTREKLPDFPAFPIYLDEDIETKVVPRSLDTGMELSAEELRALTTFTLRIFRDVFHKVYEQESEKLPYWLAPAEPLDANGREPGPRGIIDWKTVTFVQENDEIVFSRDLAPESLVNRFMFDKWDGRSRFFTIKVMEGLRAADPPPSSVPRRRHMDNIMSYCLSLSKNSRARFLAGCHWDQPVLQAELVRLRRNLLDKLTTEEKKIQTECFICAEPLKISAIPPSIASTCLAFPAIITRLDSYLISIEACDELDLVIRSDYALEAVTKDSDNTEEHRGQQIHFQRGMGKNYERLEFLGDCFLKMATSIALFTQNPDDDEFDYHVNRMCLICNKNLFNTAKKRQIYRYIRSRSFSRHVWYPDGLTLLQGKDHSKKMLSQAKHALGEKTIADVCEALIGACLLSGGPEHRFDMGVKAVSVFVDSPSHAVSRWKEYIGLYKPPNYQVRKAEGAETNLALQVEEKLGYHFRYPRLLCSAVTHPSTPSTWYFRVPCYQRLEFLGDSLLDMVCVEDLFHRFPDRDPQWLTEHKMAMVSNKFLGALAVKLGFHKHIKAFSNPLQAQITYYVEEIETAEAESEGAVDYWVVAKDPPKCLPDMVEAYLGAIFVDSDFSFEVIEAFFQAQIKPYFQDMSIYDTFANKHPTTFLHNRLANEFGCTNYCLKAGEMPAIDGMPAGVLAAVIVHNSVVSEATASSSRYAKIRASERALVVLDGLLPYEFRQRYNCNCQVVGNPASAPDIGTAI","proteome":"UP000006701","gene":"dcl1","go_terms":[{"identifier":"GO:0016891","name":"RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004525","name":"ribonuclease III activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006396","name":"RNA processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3cb3012ef4fe99cf81dd2db865e4f9f132912892","counters":{"domain_architectures":785,"entries":34,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"smart":3,"cathgene3d":3,"cdd":2,"profile":5,"ssf":2,"pfam":6,"panther":1,"prosite":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":785}}}