{"metadata":{"accession":"A0AAX6TA25","id":"A0AAX6TA25_HETGA","source_organism":{"taxId":"10181","scientificName":"Heterocephalus glaber","fullName":"Heterocephalus glaber (Naked mole rat)"},"name":"TNF receptor-associated factor","description":["Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2"],"length":426,"sequence":"MEKEELPPGFGGQDLLDTARLGKVPGPPVPAGFPPSAVISAQAVNRSAQSHRVERLRTTLHPAPNGNFGGLSTRGKQLRISQHFAHVHPEVADAGVGCPFAGVGCSFKGSPQSLQEHEATSQATHLNLLLGFMKQWKAQLGSGTGSGPTALERNLSDLQLQAAVEVPGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEEKLRVFENIVAVLNKEVEASHLALAASIHQSQLDQERILSLEQRVMELQQTLAQKDQALGKLEQGLRLMEEASFDGTFVWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLNKLQSPKHAYVKDDTMFLKCIVETGS","proteome":"UP000694906","gene":"Traf1","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005164","name":"tumor necrosis factor receptor binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042981","name":"regulation of apoptotic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a821523a507ade89eceb99915f9ed4a5069e83e8","counters":{"domain_architectures":359,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":1,"ssf":1,"cdd":1,"smart":1,"pfam":2,"pirsf":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":359}}}