{"metadata":{"accession":"A0AAV0A5P6","id":"A0AAV0A5P6_PHORO","source_organism":{"taxId":"109678","scientificName":"Phodopus roborovskii","fullName":"Phodopus roborovskii (Roborovski's desert hamster)"},"name":"Interleukin-1 receptor type 1","description":["Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells"],"length":575,"sequence":"MENMKVLLRLLCLIVPLLSLETDECKEYLHKIILFSSANEIDIRDCPLTLNEKHGAVIWYKNDSKTPISMELGSRIHQQKERLWFVPAKMEDSGHYYCVARNSTHCLRTKVTVKVLENDPGLCYNAQATFRQRLHIAGDGSLVCPYLDFFKDEKNQLPKVQWYKDCKPLPLDNINFFGAKNKLMVRNVTEEHGGNYTCHVSYTYLGTPYPVTRVIEFITIGSNKNDRPVIVSPRNETLEVAPGSRIQLVCNVTGQATDLVYWKWNGSEIEENDPFLVEDYQLVERPSARRKHTLITTLNISVVQSHFYRHPFTCFVKNSNIIESAHVKLIYPVPDFKNYIIGTFVILTATIICCVFIYKIFKVDIVLWYRDACSDFLPPKASDGKAYDAYILYPKTFREGPSSNLDTFVFKLLPEVLEGQFGYKLFICGRDDYAGEDTIEVTNEYVKKSRRLIIILMRDMGGFSWLSHSSEEQIAIYNALVREGIKVVLLELEKIQDYEKMPESIQFIKRKHGAICWSGDFKERTQHAKTRFWKNVRYHMPAPRQSSLSRHHLLTQDPVLATKEKLQAETHLPIG","proteome":"UP001152836","gene":"Il1r1","go_terms":[{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004909","name":"interleukin-1, type I, activating receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004908","name":"interleukin-1 receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"76b0a9356838de3843952d07c8936210e8064f8f","counters":{"domain_architectures":31,"entries":26,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":2,"cathgene3d":2,"smart":2,"pfam":4,"ssf":2,"panther":1,"prints":3,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":31}}}