{"metadata":{"accession":"A0AAU8B2Z4","id":"A0AAU8B2Z4_9VIRU","source_organism":{"taxId":"3145771","scientificName":"Dulem virus 60","fullName":"Dulem virus 60"},"name":"Replication-associated protein G2P","description":["Isoform G10P protein binds to double-stranded DNA and prevents hydrolysis by nucleases. Additionally, G10P is an inhibitor of DNA replication and may have a role in the transition from semiconservative replicative form DNA replication to single-stranded DNA synthesis in the life cycle","Isoform G2P plays an essential role in viral DNA replication. Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond, generating the dsDNA replicative form II (RFII). In turn, viral DNA replication initiates at the 3'-OH of the cleavage site. After one round of rolling circle synthesis, protein G2P is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single-stranded molecule ready to be packed into a virion"],"length":414,"sequence":"MIDTLEIHIPVFPAYCRSTAKDCWEIVGDVTDYGLTGNSRYVKKSDDGDNIAYDLYHAYESIPTSHTGIAFKFMHRAYKTMPFVLLNCSIAKILQGHNVYGNLDMISGACEMLGVFKEKFSEFSAYLDFSRAEVVRFDVTLPALTSSLNMAERIRDFLRNVDYGRYRSLSVRNIKEHYNTLYFGSEQSKTGGFKIYCKGIEFNKEMKELEHKALKNCIVSHALLNKVFTPDVREYAQRSIRIEATIKKRAIKEHGLSVNLWDFLVYQYRNPNIYQKLFNLKTGDFIEALKGMYMSFDDDVKLYELLLARLTTITPTGKKSTTKAQNAYNFYKRIKDDGFYEVKRTTEERTFRRNVKSLIDAGLSRAYLQSLAHSEEKPIIRLLNLDMKAENPPSYVHPVSSYFNEFSGYLQRVA","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0006260","name":"DNA replication","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"903fef800c9a6aae74a41f11bfafaa62f8643727","counters":{"domain_architectures":528,"entries":6,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"ncbifam":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":528}}}