{"metadata":{"accession":"A0AAN6MD86","id":"A0AAN6MD86_9PEZI","source_organism":{"taxId":"2831512","scientificName":"Staphylotrichum tortipilum","fullName":"Staphylotrichum tortipilum"},"name":"Thiamine thiazole synthase","description":["Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance"],"length":330,"sequence":"MAPSAVSPAQQHVQLAVAAKKAQDVVDDTTAAPAPGLTKPLADMMGNWDNFSFAPIRESTVSRAMTSRYFTDLHTHAESDIAIIGAGSCGLSAAYTLSKLRPDLRIALIEAGVAPGGGAWLGGQLFSAMVLRKPADVFLRDVGVPFEDEGDYVVVKHAALFTSAVLERVLRSGNVKMFNATAVEDLITRPCADGEGGIRVAGVVTNWTLVAMHHGDQSCMDPNTINAPVVISTTGHDGPFGAFSVKRLVSMKRLEELEGMRGLDMLRAEDAIVKNTREVVPGLIVGGMELAEIDGANRMGPTFGAMLLSGVKAAEEALRVFDLRKKQNEA","proteome":"UP001303889","gene":"C8A05DRAFT_38423","go_terms":[{"identifier":"GO:0009228","name":"thiamine biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"571e71cd852e674548876e8def22d01138018e85","counters":{"domain_architectures":3749,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":2,"hamap":1,"panther":1,"ncbifam":1,"pfam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":3749}}}