{"metadata":{"accession":"A0AAF6ZC43","id":"A0AAF6ZC43_BOVIN","source_organism":{"taxId":"9913","scientificName":"Bos taurus","fullName":"Bos taurus (Bovine)"},"name":"U1 small nuclear ribonucleoprotein C","description":["Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region","Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region"],"length":180,"sequence":"VTSSSDGHLLTGCHLFLYPPPFSRFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPTPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR","proteome":"UP000009136","gene":"SNRPC","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0030627","name":"pre-mRNA 5'-splice site binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000395","name":"mRNA 5'-splice site recognition","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000398","name":"mRNA splicing, via spliceosome","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005685","name":"U1 snRNP","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b3d4a988413dcb14e72275512e7fed5e9885436e","counters":{"domain_architectures":6436,"entries":13,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"smart":1,"cathgene3d":1,"ssf":1,"pfam":1,"profile":1,"hamap":1,"pirsf":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":6436}}}