{"metadata":{"accession":"A0AAD2YUS5","id":"A0AAD2YUS5_ECOLX","source_organism":{"taxId":"1055536","scientificName":"Escherichia coli O103","fullName":"Escherichia coli O103"},"name":"5-formyltetrahydrofolate cyclo-ligase","description":["Involved in the removal of 5-formyltetrahydrofolate. In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5-formyltetrahydrofolate (5-CHO-THF) to form 5,10-methenyltetrahydrofolate (5,10-CH=THF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT)"],"length":200,"sequence":"MTQLPELPLTLSRQEIRKMIRQRRRALTPEQQQEMGQQAATRMMTYPPVVMAHTVAVFLSFDGELDTQPLIEQLWRAGKRVYLPVLHPFSAGNLLFLNYHPQSELVMNRLKIHEPKLDVRDVLPLSRLDVLITPLVAFDEYGQRLGMGGGFYDRTLQNWQHYKTQPVGYAHDCQLVEKLPVEEWDIPLPAVVTPSKVWEW","proteome":null,"gene":"QF322_003327","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"da7902c2269b39b3671d00300f68342993ce3964","counters":{"domain_architectures":33030,"entries":10,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"ncbifam":2,"pirsf":1,"pfam":1,"panther":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":33030}}}