{"metadata":{"accession":"A0AA97KBM8","id":"A0AA97KBM8_EUBMA","source_organism":{"taxId":"481883","scientificName":"Eublepharis macularius","fullName":"Eublepharis macularius (Leopard gecko)"},"name":"Type-2 angiotensin II receptor","description":["Receptor for angiotensin II, a vasoconstricting peptide. Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation"],"length":375,"sequence":"MHASNYSTVIATEQMLEESYLSPTNVSSLSHCSVNLSSYQFVLIPVLYCILFIFGLVGNSLVIAVLCRQKNPKTVANVYIVNLAVADLLALVTVPFWASYYAYGYNWLFGSVMCKLSSSVFGLTMFASIFFITCMSMDRYQAIAHPFQSQRRTLQQASVTALLVWGLAALTSLPAFYFRDTQYIEDLNVTACVMAFPNETYSEWSAGTALMKNTLGFLIPVAIIATCYIWIRVHLMKARGLEKNKQKRDRVLKVVAAVVVAFLICWLPFHILTFLDALTWMHVIKECWIVSAIDMALPFGISMGFANSCINPLLYYFIGNQFQDKLHLFKLRLYQFNSNRQGFLSSKSSSLKDTDILKDAKHREGDSGVMQTHPL","proteome":"UP001190640","gene":"AGTR2","go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004945","name":"angiotensin type II receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006954","name":"inflammatory response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0042981","name":"regulation of apoptotic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0097746","name":"blood vessel diameter maintenance","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":394800,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":1,"smart":1,"pfam":1,"profile":1,"panther":1,"prints":3,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":394800}}}