{"metadata":{"accession":"A0AA34QVS4","id":"A0AA34QVS4_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"RISC-loading complex subunit TARBP2","description":["Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds in vitro to the PRM1 3'-UTR. Seems to act as a repressor of translation. For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1. Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation"],"length":376,"sequence":"MVAPAGTEEGMSEEEQGSGTTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDIPVFTAAAAATPVPSVVLTRSPPMELQPPVSPQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEVEPDDDHFSIGVGSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSLGSLGALGPACCRVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCHGSATTREAARGEAARRALQYLKIMAGSK","proteome":"UP000005640","gene":"TARBP2","go_terms":[{"identifier":"GO:0003725","name":"double-stranded RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0035197","name":"siRNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070883","name":"pre-miRNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046782","name":"regulation of viral transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0070921","name":"regulation of siRNA processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:1903798","name":"regulation of miRNA processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0070578","name":"RISC-loading complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7435f1472713726f6ba0a49b4f5718a73bed1d1e","counters":{"domain_architectures":7430,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":3,"profile":1,"pfam":1,"smart":1,"panther":1,"hamap":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":7430}}}