{"metadata":{"accession":"A0A9X9M5J7","id":"A0A9X9M5J7_GULGU","source_organism":{"taxId":"48420","scientificName":"Gulo gulo","fullName":"Gulo gulo (Wolverine)"},"name":"Malate dehydrogenase","description":["Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)"],"length":334,"sequence":"MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALEKYAKKSVKVIVVGNPANTNCLTAAKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKNVIIWGNHSSTQYPDVSHAKVKLQGKEVGVYDALKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGIISDGNSYGVPDDLLYSFPVTIKNKTWKIVEGLTINDFSREKMDLTAKELAEEKETAFEFLSSA","proteome":"UP000269945","gene":"BN2614_LOCUS3","go_terms":[{"identifier":"GO:0030060","name":"L-malate dehydrogenase (NAD+) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006108","name":"malate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016616","name":"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016615","name":"malate dehydrogenase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019752","name":"carboxylic acid metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"efa9ddffcabca3280ae0d7a3462c2f8e6d373a42","counters":{"domain_architectures":40953,"entries":22,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":1,"pfam":2,"ncbifam":3,"hamap":1,"pirsf":1,"panther":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":40953}}}