{"metadata":{"accession":"A0A9W2V263","id":"A0A9W2V263_PANPR","source_organism":{"taxId":"9691","scientificName":"Panthera pardus","fullName":"Panthera pardus (Leopard)"},"name":"Protein strawberry notch homolog 2","description":["Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade"],"length":1284,"sequence":"MSQLRLWLHLAALNKDSTYLDELSNASIFSSSVDSLSDIADTPDFLPADSLSQVPTIWDVSTGPSAQDKLLLPRGPWTGVEDPVSSLSSTPLLVSYQSQSQPEEEEEAEEEEGDELGHAETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLALPASDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGIILENFLRGRKKSLWFSVSNDLKYDAERDLRDIDAPGIAVHALSKIKYGDNTTSEGVLFATYSALIGESQAGGQHRTRIRQILEWCGEAFDGVIVFDECHKAKNASSTKMGKAVLDLQNKLPLARVVYASATGASEPRNMIYMSRLGIWGDGTPFRTFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFERVYNRAALLWAEALGVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCVAAKVHRLVELAREELARDKCVVIGLQSTGEARTREVLDQKDGQLDCFVSAAEGVFLSLIQKHFPSTKRKRERGVGSKRKRRPRGRGAKAPRLVCEVAGVIRISDDSSTESDAGLDSDFHSSPESVLDDDVVILDAIGLPADDRGPLCPLQRDPHGPGVLERVERLRQDLLAKVRALGRELPVNTLDELIDQLGGPEHVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHVNLREKERFMSGEKLVAIISEASSSGISLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGARALSCVLTTILSQTENKVPLPQGYPGGDAAFFRDMKQGLLSVGIGGRESRSGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIDVDKKEGKYDMGILDLAPGVDEIYEESQQVFLAPGHPQDGQVVFYKISVDRGLKWDEAYAKSLELTGPHDGFYLSYKVRDNKPSCLLAEQNRGKHFTVYKPNVGRQSQLETFDSLCRKFHWVTAEEAREHWENSYAFSLTHCSHTAWNRHCRLVQEGKDCVQGLRLRHHYMLCGALLRVWGRIAAVMADVTSSSYLQIVRLKTKDQKKQVGIKIPEGCVRRVLQELQLMDDDVKRKHARGRGLPALPPPPPPPALRPLELPCGPGEVLDLTYSPPAQAFPQPPPFAFPPPDPVPAPGGLPLGAPDSAADAAAAALAHQRRDINFKEVLEDMLRSLNAGPGAGAAGAPAGSGGPERQSVIQFGPPFPSS","proteome":"UP001165780","gene":"SBNO2","go_terms":[{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"8c09c40994542d16378810f1e37de59f493a8fd4","counters":{"domain_architectures":3582,"entries":11,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"ssf":1,"cathgene3d":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":3582}}}