{"metadata":{"accession":"A0A9W2UK97","id":"A0A9W2UK97_PANPR","source_organism":{"taxId":"9691","scientificName":"Panthera pardus","fullName":"Panthera pardus (Leopard)"},"name":"Probable cytosolic iron-sulfur protein assembly protein CIAO1","description":["Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation","Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation"],"length":339,"sequence":"MKDSLVLLARVPAHPDSRCWFLAWNPAGTLLASCGGDRRVRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCYATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPNNEQGVACSGSDPSWKCICTLSGFHSRTIYDVAWCQLTGALATACGDDAIRVFEEDPSSDPQQPTFSLTAHLPQAHSQDVNCVAWNPKEQGLLASCSDDGEVAFWKYQRPEGI","proteome":"UP001165780","gene":"CIAO1","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016226","name":"iron-sulfur cluster assembly","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0097361","name":"cytosolic [4Fe-4S] assembly targeting complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"87f0491a909b57bb621cadc1b0f405a1de582499","counters":{"domain_architectures":21012,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":3,"cathgene3d":1,"smart":1,"pfam":1,"ssf":1,"cdd":1,"hamap":1,"panther":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":21012}}}