{"metadata":{"accession":"A0A9V1E618","id":"A0A9V1E618_PANPR","source_organism":{"taxId":"9691","scientificName":"Panthera pardus","fullName":"Panthera pardus (Leopard)"},"name":"Cyclin-T1","description":["Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II"],"length":726,"sequence":"MEGERKNNNKRWYFTREQLENSPSRRFGLDPDKELSSRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRNSVAPAALFLAAKVEEQPKKLEHVIKVAHACLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIRNWRACQAPKKTKADDRGTDENTSEQTILSMISQSSSDTTIAGLMSMSTSTTSAVPSLPATEESSSNLSNVEMLQGERWLSSQPPFKLEPAQGHRTSENLALIGVDHSLQQDGSNTFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPVEGSENPERPFLEKPDKAALKMRIPVASGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKDKHKTHPSNHHHHHNHHSHKHSHSQLPAGTGNKRPGDPKHSSQTSTLAHKPYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSINFPFPPLPTMAQLPGHSSDTSGLPFTQPSCKTRVPHMKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPPAFEFVHSYGEYLNPRGGGMSSRSGNTDKPRLPPLPSEPPPPLPPLPK","proteome":"UP001165780","gene":"CCNT1","go_terms":[{"identifier":"GO:0016538","name":"cyclin-dependent protein serine/threonine kinase regulator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006357","name":"regulation of transcription by RNA polymerase II","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"dece246de228a8112079fa1205668ca2daaefef0","counters":{"domain_architectures":7222,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":2,"pfam":2,"smart":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":7222}}}