{"metadata":{"accession":"A0A9P5GMF2","id":"A0A9P5GMF2_PENCR","source_organism":{"taxId":"36656","scientificName":"Penicillium crustosum","fullName":"Penicillium crustosum (Blue mold fungus)"},"name":"Fanconi-associated nuclease","description":["Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions"],"length":763,"sequence":"MSLLNFWDMQRPAKRRRTFEREDSSTDAETKPPPSPSPSVTAGELPAADDLGIITNSQTELETSLPAIKTDEDAIEEYEALQNDKQTRLHVRLRDGAWQKGKSSIYVDAFNLALETVLDEESHLFNEAEKEIFTQWRELSYESQYLYVRLFLRKTSAWHRINRLNYYSDISDLFSVAEDLQRDRNLPDPELGNKFRFAEGIEAITTLEEASSLLLLEELKVFAKEARVQGKSKKELLAALRETSQTQTGLKDTNNRDGHFTQKILDYTGGCIRISPVPRTLFERVHLVFYRSTEWSEKSLTTIILAKMTKRNFPEYIVCRSNSIFSSREALLEFESAIQTQFAIDNILESNGPVTTESLQQIIDLAKKSYPRWKELVEQEQKKEDSIYESGEGAYLRRFSPAWVLTRIIHKSLYPLGRFKEHKREHEVLEELLAQRLFHAARRGAWYQRKALLEEHYMWALTPTDGRSEEAQRKHWKRLALRTCEAGLEDPLCHLIFHYDLQKRITKLEKALRVVKREQHDFGHVMLGKPAERTIEGIRIDTGDTPRKGKATIWVDEREGGECRVESMCLSWYRDHGWKGYHSEGGIVRTLFGYLFYDILFTYVPNVFQTAFQTCPLDLHTDVFYPSRASEINHRLVEITNGDAERIIREIHNREAGAQPCAIGLDWSFDLDDLVEIVQCFRGEALATICKVMAQEYQQRGGGIPDLFLWNYETRTVMFAEVKSENDRLSDTQRLWIHILVGAGVKVELCNAVAREVRAECDV","proteome":"UP000701341","gene":"PCG10_006956","go_terms":[{"identifier":"GO:0016788","name":"hydrolase activity, acting on ester bonds","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004518","name":"nuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0036297","name":"interstrand cross-link repair","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"d9394b5e83c204d218d5a86aa3bcba3ccd2a27aa","counters":{"domain_architectures":1139,"entries":13,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"cdd":1,"smart":1,"cathgene3d":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":1139}}}