{"metadata":{"accession":"A0A9L0TKS6","id":"A0A9L0TKS6_HORSE","source_organism":{"taxId":"9796","scientificName":"Equus caballus","fullName":"Equus caballus (Horse)"},"name":"Activating signal cointegrator 1 complex subunit 3","description":["ATPase involved both in DNA repair and rescue of stalled ribosomes. 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation"],"length":2004,"sequence":"MALPRLTGALRSFSNVTKQDNYNEEVADLKMKRSKLHEQIVGLDLTWKKIVKFLNEKLETSEMQSVNEDLKDILQAAKQIVGMDNGKEVIESAAAFLFQTFHLKDCVGHKETKAIKQMFGPFPSSSATAACNATNRITSHFHQDSLTALVQMTKEENGDRVLFGKNLAFSFDMHDLDYFDELPINGESQKTISLDYKKFMNEHFQEHSTPGLKPVEKTNDSFLWCEVEKYLNATLNEMAEATRIEDLCCTLYDMLASVKSGDELQNEIGQLAFKGMRRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTNYFSKRLEPLGIVVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVKLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPCIGLFYFDGRFRPVPLGQTFLGVKSANKVQQLNNMDEVCYESVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNNGQISCFLPSQGPEYGHAEKQVQKSRNKQVRELFPEGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDRFGEGIIITTHDKLSHYLTLLTQQNPIESQFLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLVYGISHKAYQIDPALTKHREQLVIEVGRKLDKARMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTESDILAIVSKAEEFDQIKVREEEIEELDALLNNFCELSAPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPAMTYRLLNLSKVIDKRLWGWASPLRQFPVLPPHILTRLEEKNLTVDKLKDMRKDEIGHMLHHVNIGLKVKQCVHQIPSVTMEASIQPITRTVLRVTLSICPDFTWSDQVHGTVGEPWWIWVEDPTNDHIYHSEYFIVLKKQVLSKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPVTALGCEAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVKQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIHQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPTFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMEDIIGTLRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDAMDYITWTYFFRRLIMNPSYYNLSDVSHDSVNKFLSNLVEKSLVELEHSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKERLKPECGTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPFESNPHSFDSPHTKAHLLLQAHLSRTMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNISNLVQMVVQGRWLKDSSLLTVPNIELHHLHIFRKWSSGIKGPRAGCHGFIECLPELIHACGGKDHVFSSMMENELPAAKMKQAWNFLSRLPVIDVGLSVKGWWDDSVEGHGELAITTLTSDKRDDNRWIRLHADQEYVLQVSLQRVHAGFHKGKQDSHAVTPRFPKLKDEGWFLILGEVDKRELIALKRVGYIRNHHVVSISFYTPEVPGRYIYTLYFMSDCYLGLDQQYDIHLNVTPASISAQVNEEVSDALTDLKVQ","proteome":"UP000002281","gene":"ASCC3","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"6c6e57c0780475609c5e48eedb743aecc0c5eae3","counters":{"domain_architectures":778,"entries":38,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"pfam":5,"cathgene3d":5,"smart":4,"cdd":3,"ssf":4,"profile":2,"pirsf":1,"panther":1,"interpro":13},"proteome":1,"taxonomy":1,"similar_proteins":778}}}