{"metadata":{"accession":"A0A9J7FYC8","id":"A0A9J7FYC8_CRIGR","source_organism":{"taxId":"10029","scientificName":"Cricetulus griseus","fullName":"Cricetulus griseus (Chinese hamster)"},"name":"N-lysine methyltransferase KMT5A","description":["Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration"],"length":345,"sequence":"MCKPRAVEAAAAAVAAATAPGPEMVEQRGPGRPRSDGENVFAGQSKIYAYMSPNKCSGMRSPLQEENSVAHHEVKCQGKPLAGIYKKREEKRNGGSTIRSSVKSDEQKIKDARRGPLAPFPNQKSEAAEPPKTPPQSCDPTNTVVAKQALKKPLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH","proteome":"UP001108280","gene":"Kmt5a","go_terms":[{"identifier":"GO:0042799","name":"histone H4K20 methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"df0349b27ec7a00aa89fcc9259babadd08257a80","counters":{"domain_architectures":58303,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":2,"cathgene3d":1,"cdd":1,"smart":1,"ssf":1,"panther":1,"pirsf":1,"pfam":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":58303}}}