{"metadata":{"accession":"A0A9F2QWW3","id":"A0A9F2QWW3_PYTBI","source_organism":{"taxId":"176946","scientificName":"Python bivittatus","fullName":"Python bivittatus (Burmese python)"},"name":"DNA excision repair protein ERCC-8","description":["Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes. Following recruitment to lesion-stalled RNA polymerase II (Pol II), the CSA complex mediates ubiquitination of Pol II subunit POLR2A/RPB1 at 'Lys-1268', a critical TC-NER checkpoint, governing RNA Pol II stability and initiating DNA damage excision by TFIIH recruitment. The CSA complex also promotes the ubiquitination and subsequent proteasomal degradation of ERCC6/CSB in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. Also plays a role in DNA double-strand breaks (DSSBs) repair by non-homologous end joining (NHEJ)"],"length":343,"sequence":"MLSGGSDGAIVLYDLENFSRKPCYTCKAICSVRRNHPGVHKFSVETVQWYPHDTGMFTSSSFDKTLKIWDTNTLQPADVFHFDGTVYSHHMSPVATRHCLIAVGTKSPKVQLCDFKSGSCSHILQGHTQEVLAVSWSPRYEFILATGSADSRVKLWDVRRASACLITLDQHNGEKSKAASETINTAHNGRVNGLCFTSDGLHLLTAGTDDRMRLWNSSSGENTLVNYGKVSNESKKGLRFTVSHGCSSEFAFVPCSTTVAVYTIYSGDLITTLRGHYSSVDCCVFQPNFQELYSSGRDGNILAWVPYLREPEPDDTHSEKLLSKQCLNPAYEDAWSSSDDEVG","proteome":"UP000695026","gene":"ERCC8","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006283","name":"transcription-coupled nucleotide-excision repair","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"384db74b5b94cd1cee33dedf16c3064646a93d11","counters":{"domain_architectures":50367,"entries":15,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":1,"pfam":1,"profile":2,"panther":1,"prints":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":50367}}}