{"metadata":{"accession":"A0A9D3RYS3","id":"A0A9D3RYS3_ANGAN","source_organism":{"taxId":"7936","scientificName":"Anguilla anguilla","fullName":"Anguilla anguilla (European freshwater eel)"},"name":"Major facilitator superfamily domain containing 2B","description":["Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid"],"length":523,"sequence":"MAKREKLACGSSDQLLNPAEPHFSKPLQQTEERLTICSKICFAIGGAPSQIAGSATAFFLQIYLLDVAQINPFHASVVLFVGKAWGAAMDPLVGFFITKSKWTRIGRLMPWMVGCTPFVVISYFYLWYVPPFSSGKFVWYLSFYCLYQTLIACFHVPYSALTMFLSANQKERDSATAYRMTMEVLGTLVGAAVQGQIVASAHTRNHCSAHNLTATPLENNGSAHITPVTDFLSHAKEMYMIAAGVIGGIFLLCTLVMFLGVKEKDDPYARSTGKPIPFHKGFLLVMRHWPYLTLTAAFLFIGVAIQLVQSNFVLFCTYAVDLRDHFHYIVLIILISAAVSIPLWQWFLGRFGKKTAAYCGITWMVPFTILLVCFPNLVVAYVVAVASGLSIAASMLLPWSMLPDVVDDFRRANPDSRGHEAIFYSFYVFFTKFASGISLGVSMLSLQFAGYKTRHCQQPEPVVYTLKLLMGAAPVAFILIGLAILLFYPITEEVRQKNKLSLDQLREQGLGTGSEAEDLRGEV","proteome":"UP001044222","gene":"ANANG_G00114210","go_terms":[{"identifier":"GO:0015293","name":"symporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008643","name":"carbohydrate transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"18700fec056a4a6b8afdaf19377d37db5df6a411","counters":{"domain_architectures":42036,"entries":6,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"panther":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":42036}}}