{"metadata":{"accession":"A0A9B0WIG5","id":"A0A9B0WIG5_CHRAS","source_organism":{"taxId":"185453","scientificName":"Chrysochloris asiatica","fullName":"Chrysochloris asiatica (Cape golden mole)"},"name":"Cytosolic carboxypeptidase 6","description":["Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis"],"length":494,"sequence":"MAERSQTAPEAGNDMGNDEAIGGNVSKYMVFPTGYCGQPKKGHLVFDACFESGNLGRVDQVSEFEYDLFIRPDTCNPRFRVWFNFTVENVKESQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQRLPPKNVYYYRCPDHRKNYVMSFAFCFDREDDIYQFAYCYPYTYTRFQHYLDSLQKRNMDYFFREQLGQSVQQRQLDLLTITSPDNLREGTEQKVVFITGRVHPGETPSSFVCQGIIDFLISQHPIARVLREHLVFKIAPMLNPDGVYLGNYRCSLMGFDLNRHWLDPSPWAHPTLHGVKQLIIQMYNDPKTSLEFYIDIHAHSTMMNGFMYGNIFEDEERFQRQAIFPKLLCQNAEDFSFSSTSFNRDAVKAGTGRRFLGGLLDHTSYCYTLEVSFYSYITGGTTVAVPYTEEAYMKLGRNVARTFLDYYRLNPMVEKMAVPMPRLRKEKNPPYKYPLLRGPASNYQDGKGDKKSSVNHKDPSNSF","proteome":"UP000504623","gene":"AGBL4","go_terms":[{"identifier":"GO:0004181","name":"metallocarboxypeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2411e63c3b6002cf2be3e4f9fbada48fb8115c34","counters":{"domain_architectures":8740,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":2,"ssf":1,"profile":1,"smart":1,"cdd":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":8740}}}