{"metadata":{"accession":"A0A9B0TKW5","id":"A0A9B0TKW5_CHRAS","source_organism":{"taxId":"185453","scientificName":"Chrysochloris asiatica","fullName":"Chrysochloris asiatica (Cape golden mole)"},"name":"Alkyl transferase","description":["With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol"],"length":294,"sequence":"MSWIKEGELSLWERFCANILKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAETLRWCLNLGILEVTVYAFSIENFKRSKNEVDGLMDLARQKFNRLMEEQCFLNVCFAYTSRHEISNAVKEMAWGVEQGLLEPSDISESLIDKCLYTNHSPHPDILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWNFCEAILQFQMNHSVLQKARDMYAEERKRQQLERDQAAVTKQLLQEGLQASGDAQLRRTCLHKLSARREERVQGFLQALELKRADWLARLGTASA","proteome":"UP000504623","gene":"DHDDS","go_terms":[{"identifier":"GO:0016765","name":"transferase activity, transferring alkyl or aryl (other than methyl) groups","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8876159cda9be3aef4959c6d968051615c4cbfab","counters":{"domain_architectures":1401,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"pfam":1,"ncbifam":1,"panther":1,"prosite":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":1401}}}