{"metadata":{"accession":"A0A974I3R0","id":"A0A974I3R0_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Kelch-like protein 25","description":["Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated eif4ebp1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis"],"length":588,"sequence":"MSVSNHENRKSRSSTGSMNIHLFHKPGHADSLLTQLNLLRKRNLFTDVVLLAGNRSFPCHKAVLASSSRYFEAMFSVGLKESQDREVNFQDALHPEVLELLLDYAYSARIILNEENAESLLEAGDMLQFHDIRDAAAEFLEKNLHPANCLNMMLISDAHYCERLLELSWRMCLTNFVELSKTEDFLRLPKLKLMELVLSEELEVEDESLVYEAVMGWIKFDLNIRLDDLPDLLRYVRLALLPDQYLRSLATDELVVRNKLAKEIVEEAARCRTKILQNDGVVTGFCARPRKVSQALLLLGGQTFMCDKIYVMDQKTTEIIPKTDIPSPRKECSACAIGCKVYVTGGKGAENGASKDVWVYDTLHDEWSKAGAMIVARFGHGSAELDHCLYVVGGHTAMAGSFPASPSVSLKQVEHYDPQTDKWSLVAPLREGVSNAAVVGAKLKLFVFGGTSVNREKLPKVQCFDPLQNRWTVAATCPQPWRYTGAAVLGNDVIVVGGDTEFSASSAYRFNSETYQWCRFGDVSSKRISCRAVASGNRLYVVGGYCGAQRCKTLDCYDPSTDTWSSVTTVPYSLIPTAFVSTWKYLTA","proteome":null,"gene":"enc1.2.L","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7f61b5d3f6b07650f5f2bb9693d4c92ab65b6146","counters":{"domain_architectures":4715,"entries":22,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":2,"pfam":3,"profile":1,"smart":3,"cdd":1,"pirsf":1,"panther":1,"interpro":7},"proteome":0,"taxonomy":1,"similar_proteins":4715}}}