{"metadata":{"accession":"A0A974DP53","id":"A0A974DP53_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"KAT8 regulatory NSL complex subunit 2","description":["Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA"],"length":493,"sequence":"MNRIRIHVLPTSRGRLTPVPKTHEALSCSFTHRPCSQPRIEGYDFCIKHILEDRNAPYKQCSYISTNNGRRCSNAAPKPDKKDGVAFCAEHARRNALALQAQIKKSNPGPTSESLLYQLSTYARSELGSQIQENSRSEACRILDEDSLSESDQDTVTVDQTWRGDLDSEADSLDSDQEDPLKHAGVYTAEEVTLIMREKLIRLQSLYIDQFKRLQHLLKEKKRNYLHTLKTEHETVGSSLLTGPEGLTFKERECLKRLKALRRYRKRYGVEALLHRQLKERRMLASEGASQQAHTTRSSQRCMAFIDDVRCSNPCLPMTRHCVSHICQDSSQVLFKLCSGSEDVPCNKPVPLSLSEDPCCLLHYRLPSPMYKAEPVLPEPEQMDVTPVELYLSTAELQPTENLPLEFSDDLDVVGDGMQFPPSPLLFDPSADILRSLDVQESDEEHTTTTSHSLLTAESLMGSAGQGQVQTTAASCTENVLSTPNGNADASLI","proteome":null,"gene":"kansl2.L","go_terms":[{"identifier":"GO:0000123","name":"histone acetyltransferase complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0ab69d8daa9d3cebbd9cac34da53dab3afdacd7a","counters":{"domain_architectures":2016,"entries":4,"isoforms":0,"proteomes":0,"sets":0,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"panther":1,"interpro":2},"proteome":0,"taxonomy":1,"similar_proteins":2016}}}