{"metadata":{"accession":"A0A8X8BUU8","id":"A0A8X8BUU8_POLSE","source_organism":{"taxId":"55291","scientificName":"Polypterus senegalus","fullName":"Polypterus senegalus (Senegal bichir)"},"name":"N-lysine methyltransferase SMYD2","description":["Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'"],"length":434,"sequence":"MKADGKAEGIERFISPGKGRGLRALKEFKVGDLVFMCPAYTYVLTVNERGNHCEFCFARKEGLSKCGKCKQAFYCNVNCQRGDWPMHKLECSSMCAFGENWNPSETVRLTARIIVKQKTQTEKTDSEKLLAVTEFESHLDKLDNEKKDLIQNDIAALHHFYSKHLEYPDNASLVTLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYRGTLAEVRAVQPISPGDEIFTSYIDLLYPTEDRNDRLKDSYFFSCECKECTTKEKDKAKLEIRKMNEPPKQEAVKEMIKYARNVIEEFRRAKHYKTPSELLEICELSLDKMGAVFEDSNVYMLHMMYQAMGVCLYMQDWEGAMRYGEKIIKPYSKHYPAYSLNVASMWLKLGRLYIGLEKKSLGVKALKKAIAIMEVAHGKDHHYIAEVKKELDEH","proteome":"UP000886611","gene":"Smyd2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016279","name":"protein-lysine N-methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042054","name":"histone methyltransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"cdb0e2dff944ca9f12bf7c5f8bce1b4131c3a44b","counters":{"domain_architectures":6599,"entries":20,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"profile":2,"smart":1,"cdd":1,"ssf":2,"cathgene3d":5,"pfam":2,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":6599}}}