{"metadata":{"accession":"A0A8U1F249","id":"A0A8U1F249_SALNM","source_organism":{"taxId":"8040","scientificName":"Salvelinus namaycush","fullName":"Salvelinus namaycush (Lake trout)"},"name":"F-box domain-containing protein","description":["Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation. Participates in Wnt signaling regulation, and plays a role in eye and jaw development. SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription"],"length":527,"sequence":"MEPEMEDNTLELMNTSVMESQNHVDDLSPKKTTILTKFSNGPVMTGSRKRPSEGNCDKEQCIALFDQWSETDQVEFVEHLISHMCHYQHGHINTYLKPMLQRDFITALPAQGLDHIAENILSFLDAQSLCSAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERHQWEKYLFKNRTTEVPPNSYYHSLYPKIIQDIETIEANWRCGRHNLQRIQCRSENSKGVYCLQYDDDKIISGLRDNSIKIWDKQSLECLKILTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVTSGEVLNTLIHHNEAVLHLRFCNGLMVTCSKDRSIAVWDMASPTDISLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVSTNGQSEGRSPSRTYTYISR","proteome":"UP000808372","gene":"LOC120062303","go_terms":[{"identifier":"GO:0046983","name":"protein dimerization activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e4853a01753e4898f98eb9e3c854a1bff495839d","counters":{"domain_architectures":3390,"entries":28,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"smart":3,"pfam":3,"ssf":2,"cdd":2,"profile":3,"panther":1,"prosite":1,"prints":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":3390}}}