{"metadata":{"accession":"A0A8U0REV5","id":"A0A8U0REV5_MUSPF","source_organism":{"taxId":"9669","scientificName":"Mustela putorius furo","fullName":"Mustela putorius furo (European domestic ferret)"},"name":"Methylthioribulose-1-phosphate dehydratase","description":["Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death"],"length":221,"sequence":"MSGCHAPEGDCGSRRCGAQDKEHPRYLIPELCKQFYHLGWVTGTGGGISLKHGNEIYIAPSGVQKERIQPEDMFVCDINEQDISGPPPCKNLKKSQCTPLFMNAYTMRGREFKITHQEMIKGIRKCTSGGYYRYDDMLVVPIIENTPEEKDLKERMARAINEYPDSCAVLVRRHGMYVWGETWEKAKTMCECYDYLFDIAVSMKRVGLDPTQLPVGENGIV","proteome":"UP000000715","gene":"LOC101685991","go_terms":[{"identifier":"GO:0046872","name":"metal ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019509","name":"L-methionine salvage from methylthioadenosine","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"88b5949af4437eee368b582b7bd45779a910fc07","counters":{"domain_architectures":64096,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":1,"pfam":1,"hamap":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":64096}}}