{"metadata":{"accession":"A0A8U0R8A1","id":"A0A8U0R8A1_MUSPF","source_organism":{"taxId":"9669","scientificName":"Mustela putorius furo","fullName":"Mustela putorius furo (European domestic ferret)"},"name":"Caspase-9","description":["Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC"],"length":437,"sequence":"MDEADRQILRRCRVQLVNELQVAPLWDVLLTRQLFTPAMIEDIQHAGSGSRSDQARQLVIDLETRGSQALPLFISCLEDTDQNKLASVLRALRQAEKQNPEVIRPQDPMPVVVRALGLTPEDLRGKQGPSKATPGKLAPVVLGPEQLWPAKLRPEVLRPEMPRPVDSGSGRFSDVCAPEISKQNADLAYALNADPCGHCLIINNVNFCLESRLTARTGSNIDCEKLRQRFHLLHFMVEVKCDLTAKQMVQALVELARRDHSALDCCVVVVLSHGCQASHLQFPGAVYGTDGCPVAIERIVNIFNGAGCPSLGGKPKLFFIQACGGEQKDHGFEVASASPEDRTPGSDPESDAVPFQEGPGPCDQPDAVSSLPTPSDIFVSYSTFPGFVSWRDTKSGSWYVETLDGVFEQWAHSEDLQTLLLRLRYGSSPSVHPQMRG","proteome":"UP000000715","gene":"CASP9","go_terms":[{"identifier":"GO:0042981","name":"regulation of apoptotic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008234","name":"cysteine-type peptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004197","name":"cysteine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5fe924bb2ee96ddea1d8c53ee09651e2b64e5aea","counters":{"domain_architectures":3445,"entries":29,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"smart":2,"profile":3,"cathgene3d":2,"cdd":2,"pfam":2,"pirsf":1,"panther":1,"prosite":2,"prints":1,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":3445}}}