{"metadata":{"accession":"A0A8T1VDY5","id":"A0A8T1VDY5_9STRA","source_organism":{"taxId":"221518","scientificName":"Phytophthora pseudosyringae","fullName":"Phytophthora pseudosyringae"},"name":"Endonuclease III homolog","description":["Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines"],"length":351,"sequence":"MRSILARPSLRRIASSSLTDPVATTLGGMRLRSSGPVDGDTSLEKKAMAMKLEGGHPPSPLRPARRRHSGKTEDENVGIKREKAERTEEETLRTPKKKAKKAAVKKERVPRKEPEGWKEILRGIEEMRAKKDAEVDKYGCEVFFDESFPPQVCRFHVLIAAMMSSQTKDPVNAAAMGRLIKRGLTVESMLEIDQQELAQLIRPVGFFNHKAKYIKQTASILTKQAEAEGKEDVDIPNTYEGLIALPGVGPKMATLVMNCAWNNTVGICVDTHVHRISNRLKWVKTWNKNNPKSQNPEKTRTELEDWLPKEHWGPINPLLVGFGQTICLPRGPKCNDCKIRGSCPSANSSAI","proteome":"UP000694044","gene":"NTHL1_3","go_terms":[{"identifier":"GO:0006284","name":"base-excision repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003906","name":"DNA-(apurinic or apyrimidinic site) endonuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019104","name":"DNA N-glycosylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006285","name":"base-excision repair, AP site formation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ddd5072a1223698000690500e0e6a81f15308649","counters":{"domain_architectures":16761,"entries":9,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"pfam":2,"smart":1,"panther":1,"hamap":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":16761}}}