{"metadata":{"accession":"A0A8T0BEA6","id":"A0A8T0BEA6_SILME","source_organism":{"taxId":"175797","scientificName":"Silurus meridionalis","fullName":"Silurus meridionalis (Southern catfish)"},"name":"Dual specificity protein phosphatase","description":["Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate","Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2"],"length":203,"sequence":"MKKLHHSPAKLAAEVRVPEGEATVQQLNELLSDSSGFYSLPAQHFNEVFPRIYIGNAFVAQNVMRLQRLGITHILNTAEGNSFMHVNTNSEFYAGSGITYHGIKANDTEQFNLSAFFEEGADFIDKALAHANGKGKVYVHCREGYSRSPTMVIAYLMLYHKMDVRVATATVRHKREIGPNDGFLRQLCQLNDKLAKEGKLKTK","proteome":"UP000606274","gene":"HF521_020611","go_terms":[{"identifier":"GO:0006470","name":"protein dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016311","name":"dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008138","name":"protein tyrosine/serine/threonine phosphatase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"15742d355813370d995348f784781e84405a14d7","counters":{"domain_architectures":46212,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"smart":1,"profile":2,"pfam":1,"panther":1,"prints":2,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":46212}}}