{"metadata":{"accession":"A0A8R2A2K5","id":"A0A8R2A2K5_ACYPI","source_organism":{"taxId":"7029","scientificName":"Acyrthosiphon pisum","fullName":"Acyrthosiphon pisum (Pea aphid)"},"name":"DNA replication licensing factor MCM5","description":["Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity"],"length":729,"sequence":"MEGFDTPGIFFSDTFGDDDNLASSLLNIRTIKKSFKEFLKTYNEENFNYKYRDTLKRNCNLGQFCLEINVEDLAGFDENLADKLYKQPVEHLPAFEEAATELAKELLASDNLEDIERVQILLSTNSLASYLRSIKSESVSRLVKIPGIIVSASSIRAKATQITLQCRSCRNVVPHLPVKPGMDGYILPRKCTTEQAGRPQCPLDPYFIIPDKCKCVDSQILKLQELSDSTPQGEMPRHVQLYCDRYLCERVVPGNRVMVVGVYSIKKVKTAKKQNVTDNSRTVVGVRAPYLRVLGFQLDDNVGGSTSLLPTSVEEEELFRKLSSSPDIYDRIAKSIAPSIFGFSDIKKAIACLLFGGSRKRLPDGLTRRGDINLLLLGDPGTAKSQLLKFVQQVSPIGVYTSGKGSSAAGLTASVTRDPTSHNFVVEGGAMVLADSGVVCIDEFDKMREGDRVAIHEAMEQQTISIAKAGITTTLNSRCSVMAAANSVFGRWDDSKGEDNIDFMPTILSRFDMIFIIKDEHDQNRDMTLAKHIMNVHLMNGQAKQEVEGELPLATIKKLINYIRRRCGPRLSEEAGEKLKSRYVIMRTGCHELESEKKLAIPITVRQLEAIIRIAESLAKMQLQPFATDSHVDEALRLFQVSTLSAATSGCLSGVEGFSTEEDTETLQRIEKQLKRRFPIGSQVSEFSIIQDFLRQKYPQRAIDKVIYLMIRRGEIQHIMQRKMLIRLK","proteome":"UP000007819","gene":null,"go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006260","name":"DNA replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003688","name":"DNA replication origin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006270","name":"DNA replication initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0042555","name":"MCM complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"335ec2adb3196e10044fc70a5b7766cb54f5aa23","counters":{"domain_architectures":3433,"entries":28,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"pfam":5,"ssf":2,"smart":1,"profile":1,"cdd":1,"panther":1,"prosite":1,"prints":2,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":3433}}}