{"metadata":{"accession":"A0A8M1MNJ8","id":"A0A8M1MNJ8_NEOSC","source_organism":{"taxId":"29088","scientificName":"Neomonachus schauinslandi","fullName":"Neomonachus schauinslandi (Hawaiian monk seal)"},"name":"Polyribonucleotide 5'-hydroxyl-kinase Clp1","description":["Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing"],"length":425,"sequence":"MGEEANDDKKPTTKFELERETELRFEVEASQSVQLELLAGMAEIFGTELTRNKKFTFDAGAKVAVFTWHGCSLQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGSGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSVDLEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK","proteome":"UP000248481","gene":"CLP1","go_terms":[{"identifier":"GO:0051731","name":"polynucleotide 5'-hydroxyl-kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006396","name":"RNA processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0031124","name":"mRNA 3'-end processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005849","name":"mRNA cleavage factor complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"72973d5732ae84186a044fefb8451431fdf44114","counters":{"domain_architectures":3653,"entries":18,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":1,"cdd":1,"pfam":3,"panther":1,"hamap":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":3653}}}