{"metadata":{"accession":"A0A8M1M7E1","id":"A0A8M1M7E1_NEOSC","source_organism":{"taxId":"29088","scientificName":"Neomonachus schauinslandi","fullName":"Neomonachus schauinslandi (Hawaiian monk seal)"},"name":"Cellular tumor antigen p53","description":["Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression"],"length":471,"sequence":"MDQMSSRAASASPYTPEHATSVPTHSPYAQPSSTFDTMSPAPAIPSNTDYPGPHHFDVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSAPPPPGTIVRAMPVYKKAEHVTEVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVMVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHQREQQALSESAAKHGAASKRAFKQSPPAVPALGTNVKKRRHGDEDVYYMHVRGRDNFEILMKVKESLELMELVPQQLVDTYRQQQQLLQRPFLTGLGCPNCIEYFTSQGLQNIYHLQNLTIEDLGALKIPDQHRMTIWRGLQDLKQSHDYGAQQLIRSSSNASTISIGSSGELQRQRVMEAVHFRVRHTITIPNRGAPAGGAGPDEWADFGFDLPDCKSRKQSIKEEFMESEIH","proteome":"UP000248481","gene":"TP73","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0000976","name":"transcription cis-regulatory region binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051262","name":"protein tetramerization","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006915","name":"apoptotic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"032b398a94e0f9bff746bbb609c9a5c1bbf089e0","counters":{"domain_architectures":64,"entries":22,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":3,"pfam":3,"cdd":1,"panther":1,"prints":1,"prosite":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":64}}}