{"metadata":{"accession":"A0A8M1GSW6","id":"A0A8M1GSW6_URSMA","source_organism":{"taxId":"29073","scientificName":"Ursus maritimus","fullName":"Ursus maritimus (Polar bear)"},"name":"Mediator of RNA polymerase II transcription subunit 21","description":["Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors"],"length":74,"sequence":"MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFSNIQTAINKDQPANPTEVISFFRICPAFCSTDCTNSKRH","proteome":"UP000261680","gene":"MED21","go_terms":[{"identifier":"GO:0016592","name":"mediator complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f7a07e05ddf412899bc3cb8db294ca05ac54bbeb","counters":{"domain_architectures":4627,"entries":6,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":4627}}}