{"metadata":{"accession":"A0A8M1GAF7","id":"A0A8M1GAF7_URSMA","source_organism":{"taxId":"29073","scientificName":"Ursus maritimus","fullName":"Ursus maritimus (Polar bear)"},"name":"Ceruloplasmin","description":["Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis"],"length":1053,"sequence":"MQLYPQREHSDIYLQNGPDRIGRLYKKALYLQYTDKTFTTVIEKPTWLGFLGPIIKAETGDEVYVHLKNFASRPYTFHPHGITYHKEHEGAIYPDNTTDFYKADDKVYPGEQYTYVLDANQDQSPGEEDSNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDYEKEKNIDQEFVVMFSVVDENLSWYLDDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVRWYLFGMGNEVDVHAAFFHGQVLTNKNYRIDTVNLFPATLFEAFMVAQNPGEWLLSCQNLNHLKAGLQAFFQVQDCNKTSSEDNIRGKHVRHYYIAAEEIIWNYAPSGIDVFTKESLTAPGSASEVFFKQGTTRIGGSYKKLVYREYTDASFTNQKKRGPEEEHLGLLGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRVSKNNEGTYYTSHHNPLSEGVPPPSASHVAPKQTFTYEWTVPKEVGPTYKDPVCLSKMYYSAVDPTKDIFTGLIGPMKICRKGSLRANGRPKDVNKEFYLFPTVFDENESLLLDDNIRMFTTAPHLVNKEDEDFQESNKMHSMNGFMYGNQPGLNMCRGDSVMWYLFSAGNEADVHGIYFTGNTYLSKGERRDTANLFPQTSVTLLMEPDTEGTFDVECLTTDHYTGGMKQKYTVNKCRRMSDDPSVHLPERTYYIAAVEVEWDYSPSREWERELHRLQEQNVSNPFLDKEEFYIGSKYKKVVYRQYTDSTFRVPAERKAEGEHLGILGPQLHADVGDIVKIIFKNMATRPYSIHAHGVKTESSTVTPTLPGEIHTYIWKIPERSGAGIEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRSYTKVFNPITKLEFSLLFFVFDENESWYIDDNIKTYSEHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVSWYLMGMGNEIDLHSVHFHGHSFRYQHRGIYSSDVFDVFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLPNKASSQTHKRIWNVIYSFTVSVIILFQISTREWLGV","proteome":"UP000261680","gene":"LOC103678054","go_terms":[{"identifier":"GO:0005507","name":"copper ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f6a3edbdd39ce94377a40cff16d31bc54dbe637f","counters":{"domain_architectures":440,"entries":20,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":3,"cdd":4,"panther":1,"prosite":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":440}}}