{"metadata":{"accession":"A0A8J2BPW3","id":"A0A8J2BPW3_9BACT","source_organism":{"taxId":"2744239","scientificName":"Candidatus Methylacidithermus pantelleriae","fullName":"Candidatus Methylacidithermus pantelleriae"},"name":"Serine hydroxymethyltransferase","description":["Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism"],"length":731,"sequence":"MKYVLFVCTGNICRSPMALGLFRDLVKGRTDIEADSAGIGAVSGLPASPHAITVMEEIGIDISDIRSKPITAELVRRADYIFCMSYSQLDSLLLLFPSAAEKTYLLREFEEDVPLIAREIPDPIGGSLEVYRFCRDQIAKALPKVVDFVLSSETGAKQPAPAGAKRVALASDHTGIALKEVVRDWLKQEGYVAHDLGPFCPEPVDYPDYAGKVGRNIRDGEAQWGIMIGENPFAIAVAANKILGVRAVAVEDPQQAEMCRREFNANLLCLPSQLRPSSNLDSILRRWFATPFSQGPYKRQVQKIEALAKLSHKVVGSSEWPPSLAEVDQEIAACIEREARRQSENLELIASENFASRAVQEAQGSCLTNKYAEGYPGRRWYGGCQNVDEIEVLAIERAKKLFGAEYVNVQPHSGSQANMAVYFAVLQPGDTIVAMDLSHGGHLTHGHRMNFSGRFFQVVSYGVRREDERLDYEEIEKLAFTHRPKLIMAGASAYPRILDFARLSQIAQAVGAYLFVDMAHIAGLVAAGLHPSPLPYADFVTTTTHKTLRGPRGGVIFAKAKYAKILDAQVFPGIQGGPLPHVIAAKAVAFYEALQPSFKAYQEQVVRNAKALAEGLRKHGYRLVSGGTDTHLLLVDLRAQGITGRQAQDLLDRAGITVNKNAIPFDTLPPAQAGGIRLGTPAVTTRGMKEEEMFQIADWIHEVFQSQDQPQKLEAIRKEVWDLTARFPLPF","proteome":"UP000663859","gene":"glyA","go_terms":[{"identifier":"GO:0016853","name":"isomerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005975","name":"carbohydrate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004372","name":"glycine hydroxymethyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030170","name":"pyridoxal phosphate binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019264","name":"glycine biosynthetic process from L-serine","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035999","name":"tetrahydrofolate interconversion","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004725","name":"protein tyrosine phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006470","name":"protein dephosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a7aa6c446dfeb1591729d1a09b85e0b59957ec35","counters":{"domain_architectures":17,"entries":31,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cdd":2,"ssf":3,"cathgene3d":4,"smart":1,"pfam":3,"ncbifam":2,"panther":1,"hamap":1,"prosite":1,"prints":1,"interpro":12},"proteome":1,"taxonomy":1,"similar_proteins":17}}}