{"metadata":{"accession":"A0A8J1MTE4","id":"A0A8J1MTE4_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase","description":["Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses"],"length":1189,"sequence":"MHEQHIFWYPKGESSSKSLVTLRVDTMGFYLYWTCPNMEVDILDISVIRDTRTGKYAKIPKDTKMREILGFTGPEQRPEDKLVTVVYGNDIVNISFLNFMAVQEDTAKIWTEELFKLAHNILAQNSSRNTFLQKAYTKLKLQVNQDGRIPVKNILKMFAADKKRVETALESCGLNFNRGDSIKPEEFTLDIFERFLNKLCLRPDIDKILLELGAKGKPYLTLEQLMDFLNQKQRDPRLNEILFPPLKRDQVRQLIEKYEPNRQFLDRDQMSMEGFSRFLGGHENSIVPPEILDLSDDMNQPLSSYFINSSHNTYLTAGQLTGNSSVEMYRQVLLTGCRCIELDCWKGRPQDEEPFITHGFTMTTEIPFKEVIEAIAESAFKTSPFPVILSFENHVDSSKQQAKMAEYCRNIFGDALLIDPLEKYPLQPGVALPSPQELMGKILVKNKKRHKVAVKGPEGSVKRRVSEQTSNTYSDSSSVCESSATGLPPSESADVSLTLSNGDEKIEEKPPKYTEPRKSIDHDAYSEEEEEEEPSDPKKSDEGTASSEVNATEEMSTLVNYVEPVKFKSFDAAKKRNKYYEMSSFVETKALEQLTKSPMEFVEYNKKQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTLDLPMQLNVGIFEYNRRSGYLLKPEFMCRTDKHFDPFTENIVDGIVANTVKIKIISGQFLSEKRVGIFVEVDMFGLPVDTKRKFRTKTSQGNSFNPVWDEEPFILPKVVLPTLATLRIAVFEEGGKFVGHRILPVSAIRPGYHYICLRNELNQPVCLPALLVYTEVNDYIPDDHQGYANALTNPIKHISLMDQRAKQLAALMGENEQPFNKDKIDWDPISKPPIRSRDDTPEKIKIPIIPVPSPPAQRDDHIASVLTDIQAPTMEELKSQKSFEKLICRQYRELRQLRRKHLRKVSSLCKEQSTWVTPLQSLRRRKPFGRSHRGVSGADQDAEQKLMDMQRDQQKRLLELREIQHEQERKLKHSHLLQAVQKLQEVAISYHSTQLKKLKEINEKEKKELQKILDRKRHNSITEAKSRERQKKDVELTEINRRHINESVSSIRRLEEAQKRRQEKLQTAHQETLQRIKDEEPKLQAQLDEACQAEFCQLPQEVRRYLQEDGWVGSGSGPPSSSHSSPPSITRSWGSESGEKDSLHSPGDSSDEATRL","proteome":"UP000186698","gene":"plcb3.L","go_terms":[{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006629","name":"lipid metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004435","name":"phosphatidylinositol-4,5-bisphosphate phospholipase C activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016042","name":"lipid catabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"0c67981c2cb5936a0a344275925573d927a3144f","counters":{"domain_architectures":2362,"entries":41,"isoforms":0,"proteomes":1,"sets":8,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":5,"ssf":5,"cdd":4,"pfam":6,"profile":3,"smart":3,"pirsf":1,"panther":1,"prints":1,"interpro":12},"proteome":1,"taxonomy":1,"similar_proteins":2362}}}