{"metadata":{"accession":"A0A8J1JMY0","id":"A0A8J1JMY0_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"D-ribitol-5-phosphate cytidylyltransferase","description":["Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not involved in dolichol production"],"length":344,"sequence":"MKAIIHKYGHQRVTLVKGGETRHRSIFNGLKVFSENHSDDTAIDKPEVVIIHDAVRPFVDEDFLLQVAKSAKQHGAAGAIRPLVSTVIASSSDGFLDYSLERARHRASEMPQAFQYDVIYRAYLQCTDYDLDFGTECLHLALQYSNVKAKLLEGPPDLWKVTYKRDLYAAESVIKESISQQLCIVTNVKKEAIEVGFLLHENLKLHYKQVKAVSSSMCKTIHHLQNIFHGQCCNFICINVKDLDFEETQNLVDLLQTTNASISYPLVIVSVHLTTEDSSSGNKLSGVRKLAKEAHKSNILVYGLLINIDQDKVQLQQTVCEGTAIITALIKDRNPALVGQLMVA","proteome":"UP000008143","gene":"crppa","go_terms":[{"identifier":"GO:0070567","name":"cytidylyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008299","name":"isoprenoid biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"f900ad3d220e7dd429bad9a01e037b72bc5d1fe5","counters":{"domain_architectures":874,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":2,"panther":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":874}}}