{"metadata":{"accession":"A0A8J0UVH3","id":"A0A8J0UVH3_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"adenylate cyclase","description":["Adenylate cyclase that mediates formation of both cyclic AMP (cAMP) and cyclic di-AMP (c-di-AMP). Acts as a key mediator of G protein-coupled receptor signaling by catalyzing the formation of cAMP downstream of G protein-coupled receptors. Functions in G protein-coupled receptor signaling cascades activated by thrombin, sphingosine 1-phosphate, dopamine and anaphylatoxin C5a. Mediates regulation of cAMP synthesis through synergistic action of the G alpha protein G(s) (GNAS) with G(13) (GNA13). Also involved in inflammation by acting as a diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into c-di-AMP. Following activation by TLR9, mediates formation of c-di-AMP, which directly activates NLRP3, thereby promoting assembly and maturation of the NLRP3 inflammasome. It is also required for the optimal functions of B- and T cells during adaptive immune responses by regulating cAMP synthesis in both B- and T-cells","Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling"],"length":1065,"sequence":"MKMPSKGKYFINDNEDWMISHSLYEKYQCISQHYPLLLILLFVMGTYCITLIALFFIYNQEPSTNLAFIITVFVALVVFCALYILVYTESFVQKWLRVFSLVIYICLLTIGYVLTFDSSVVHTWDQVPFFLFITFSVYTMLPLGMQTCVIISIISGISHIIVISITVVLCSGSNDAIAFQLIANAVIFLCGNLMGAYHKYHMQDASRDLYSYTVKCIRIKMKLELKKRQQESLLLSVLPVYISMEMKLAIQDRLTETNDNRQPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPVSLPNNAKNCVKMGLDICESIKQVREATGADINMRVGVHSGNVLCGVIGLRKWQFDVWSHDVSLANRMESAGLPGRVHITEATLKHMNGAYDVEEGHGELRDPYLKEMNIKTYLVIDPRAKNRRVQNIHLPKHRVNDGLKVRPSVRMTRYLESWGAARPFSHFDQSDASSAEVPVVNGKPKLDIPLKGMGRTVKTERNVSQKRNQEEELHDRMMNTIDGLSSAKPWFGKTDDFYGFLLFFTADGLEKEYRTFRIPCIRNYFLCASLIFLGIFLIQILVMPRNANLGISFGVVSILIIWVLLLCYADKCVRFFNESAPFSRFLCSLVEMIETRPSLRVPLVALTLGSLLIISIVNLPLDQTLQTCNASSLATESKCQSIPYYIYCCILGLIACSMFLRLCFELKILLLTAAFTAYNVIIFHTHSSIFRSNLPVTSPIGVLEDFQKMSCFYLSLYYLTLVLLARQVEYYSRLDCLWKRKFRKEDEEIETMENLNQLLLENVLPAHVAAYFIGDNKSNEDLYHQSYDCVCVMFASVPEFKVFYTECDVNKEGLECLRLLNEIIADFDELLMKPKFSGVEKIKTIGSTYMAATGLTATPGQENQDQEKQHALIGITVEYAMALMSKLDGINRHSFNNFSLRVGINHGPVIAGVIGAKKPQYDIWGNTVNVASRMESTGELGKIQVTEETCQILEGLGYSCECRGFINVKGKGELRTYFVCTDMAKSQSIGMN","proteome":"UP000186698","gene":"adcy7.L","go_terms":[{"identifier":"GO:0009190","name":"cyclic nucleotide biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004016","name":"adenylate cyclase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006171","name":"cAMP biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005886","name":"plasma membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016849","name":"phosphorus-oxygen lyase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"477ab5fb934d4ba4d65c0403a72a413e8810db5d","counters":{"domain_architectures":7007,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"ssf":1,"pfam":3,"cdd":1,"profile":1,"panther":1,"pirsf":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":7007}}}