{"metadata":{"accession":"A0A8J0T5E5","id":"A0A8J0T5E5_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Nucleolysin TIAR","description":["RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation. Shows a preference for uridine-rich RNAs. Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA. Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis"],"length":445,"sequence":"MSGFSLTGYWPLPPFCFEPDGVRQDLLFAPVLRPSPPPPPCPLTHFPLENPGSPTDMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQTDGRRVGASVSFPVLPNANNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATSKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFDDVVNQSSAKNCTVYCGGIGSGLTEQLMRQTFGVFGQILEIRVFPEKGYSFIRFSTHDSAAHAIVSVNGTTIEGHVVKCYWGKETPDMTKNFQQVDYSQWGQWGQMYGSPQQYGQYVTNGWQVPSYGVYGQAWNQQSFGVDQSPSTAWVGGFSAQPPPQGQAPPVIPNPPGYSMASYQTQ","proteome":"UP000186698","gene":"tial1.S","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"1d8d02f5f54dae87c0a5dfa9c17a8ccb9f1ee753","counters":{"domain_architectures":44858,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"profile":1,"smart":2,"cdd":3,"pfam":1,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":44858}}}