{"metadata":{"accession":"A0A8I6A673","id":"A0A8I6A673_RAT","source_organism":{"taxId":"10116","scientificName":"Rattus norvegicus","fullName":"Rattus norvegicus (Rat)"},"name":"NEDD8-activating enzyme E1 catalytic subunit","description":["Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8","Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression"],"length":456,"sequence":"HQVGEECFPTIDKPKLEKLTTQMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDVGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGDGVPLDGDDPEHIQWIFQKSVERASQYNIRGVTYRLTQGELVNCHSCGIAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFT","proteome":"UP000002494","gene":"Uba3","go_terms":[{"identifier":"GO:0008641","name":"ubiquitin-like modifier activating enzyme activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019781","name":"NEDD8 activating enzyme activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0045116","name":"protein neddylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"aa9b3c9b2e1b62d59195a2a2c54d7f5cdbad21a7","counters":{"domain_architectures":4607,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":1,"pfam":2,"cdd":1,"smart":1,"panther":1,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":4607}}}