{"metadata":{"accession":"A0A8I5ZX76","id":"A0A8I5ZX76_RAT","source_organism":{"taxId":"10116","scientificName":"Rattus norvegicus","fullName":"Rattus norvegicus (Rat)"},"name":"Eukaryotic translation initiation factor 3 subunit K","description":["Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression"],"length":218,"sequence":"MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLTDNQLRVWMSKYGWSADESGQVFICSQEESIKPKNIVEKIDFDSVSSIMASSQ","proteome":"UP000002494","gene":"Eif3k","go_terms":[{"identifier":"GO:0003743","name":"translation initiation factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0043022","name":"ribosome binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006446","name":"regulation of translational initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005852","name":"eukaryotic translation initiation factor 3 complex","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0f21178934646dc825a7ffdf8ebd8a66ab66968f","counters":{"domain_architectures":11359,"entries":15,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"profile":1,"panther":1,"hamap":1,"pfam":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":11359}}}