{"metadata":{"accession":"A0A8I3RZ44","id":"A0A8I3RZ44_CANLF","source_organism":{"taxId":"9615","scientificName":"Canis lupus familiaris","fullName":"Canis lupus familiaris (Dog)"},"name":"Phosducin-like protein 3","description":["Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis"],"length":240,"sequence":"MQDPNADTEWNDILRKKGILPSKESLKDLEKEAEEEEQRVLQQSVVKTYEDMTLEELEDNEDEFNEEDERAIEMYRQQRLAEWKATQLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCALINQHFSGLARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTIDELEWKLSESGAIKTDLEENPKKPIEDTLLSSVRCSIPTRRDSDSEDD","proteome":"UP000805418","gene":"PDCL3","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e8fbfbb32957e2f1bdd157a9533cc44d59b58f9f","counters":{"domain_architectures":11336,"entries":9,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cdd":1,"pfam":1,"cathgene3d":1,"panther":1,"ncbifam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":11336}}}