{"metadata":{"accession":"A0A8I3MHT7","id":"A0A8I3MHT7_CANLF","source_organism":{"taxId":"9615","scientificName":"Canis lupus familiaris","fullName":"Canis lupus familiaris (Dog)"},"name":"Inactive rhomboid protein","description":["Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own"],"length":866,"sequence":"MEARPAPRGTMSEARRDSASSLQRKKPPWLKLDIPAAAPPAPEEPSCLQPLRRQAFLRSVSMPAETAPVPSPHPELRRLGLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTADGLSTPHTPVTPGAASLCSFSSSRSGFNRFPRRRKRESVAKMSFRAAAALVKGRSVRDGTLRRVQRRSFTPASFLEEDTADFPDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWEKATEQGDLTGGALDRSELERSHLMLPLERGWRKQKEGGAAVPQPKVRLRQEVVSTAGQRRGQRIAMPVRKFFAREKRPYGLGMVGRLTNRTYRKRIDSYVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIRAAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPLHPSAPDLAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPDDITKWPICTKNSAGNHTNHPHMDCVLTGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSVCFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQVLARPWRAFFKLSAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIVFQVVFLGLLAGLVILFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH","proteome":"UP000805418","gene":"RHBDF1","go_terms":[{"identifier":"GO:0004252","name":"serine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d8b3f10549de7c0a88b519f5602369bccae32757","counters":{"domain_architectures":2460,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"ssf":1,"cathgene3d":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":2460}}}