{"metadata":{"accession":"A0A8F9WU71","id":"A0A8F9WU71_9FLAV","source_organism":{"taxId":"11083","scientificName":"Powassan virus","fullName":"Powassan virus"},"name":"Genome polyprotein","description":["Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter","Inhibits RNA silencing by interfering with host Dicer","May play a role in virus budding. Exerts cytotoxic effects by activating a mitochondrial apoptotic pathway through M ectodomain. May display a viroporin activity"],"length":3415,"sequence":"MVTTSKGKGGGPPKRKLKVTANKSRPATSPMPKGFVLSRMLGILWHAMTGTARTPVLKMFWKTVPLRQAESALKKIKRVIGNLMQSLHMRGRRRSGVDWTWTFLVMALMAMAMATSIHRDKEGYMVMRASGRDAASQVRVQNGTCVILATDMGEWCEDSITYSCVTIDQEEEPVDVDCFCRGVDRVKLEYGRCGRQAGFRGRRSVVIPTHAQKDMVGRGHAWLKGDNIRDHVTRVEGWMWKNKLLTVAVVALAWLMLDSWMARVTVILLALSLGPVYATRCTHLENRDFVTGVQGTTRVSLVLELGGCVTITAEGKPSIDVWLEDIFQESPAETREYCLHAKLSNTKVEARCPTTGPATLPEEHQANMVCKRDQSDRGWGNHCGFFGKGSIVACAKFECEEAKKAVGHVYDSTKITYVVKVEPHTGDYQAANETNENRKTAQFTVASEKVILNLGDYGDVSLTCKVASGIDVAQTVVMSLGSNKDHLPSAWQVHRDWFEDLALPWKHKDNQDWNSVEKLVEFGPPHAVKMDIFNLGDQTAVLLKSLAGVPLASVDNQKYHLKSGHVTCDVGLEKLKLKGTTYSMCDKTKFKWKRVPVDSGHDTVVMEVSYTGSDKPCRIPVRAVAHGVPTINVAMLITPNPTIETSGGGFIEMQLPPGDNIIYVGDLSQQWFQKGSTIGRMLEKTRKGLERLSVVGEHAWDFGSVGGILSSVGKAVHTVLGGAFNTLFGGVGFIPKMLLGVALVWLGLNARNPTMSMTFLAVGVLTLMMTMGVGADYGCAVDPERMEIRCGEGLVVWKEVSEWYDGYAYHPESPDTLAQALREAFERGICGVVPQNRLEMAMWRSTAPELNLVLSEGEANLTIVVDKTDPADYRGGTPMALKKTGKESKVSWKSWGKSILWSVPESPRRMMMGVDGAGECPLHKRATGVFTVAEFGVGLRTKVFLDLRGEASRECDTGVMGAAVKNGKAIHTDQSMWMSSFRNGTGTYIQELILTDLRNCTWPASHTIDNDGVLDSRLFLPVTLAGPRSKYNRIPGYSEQTKGPWDQTPLRVVRDHCPGTSVKIDSQCDKRGASVRSTTESGKIIPEWCCRACELPPVTFRSGTDCWYAMEIRPVHSQGGLVRSMVMADNGAMLSEGGTPGLVAVFVLMEFLLRRRPGSVTSILWGGILMLGLLVTGLVRVEEIVRYIIAVGITFHLELGPEIMALVMLQAVFSMRTCYLIGFLVKRVITTREVVTVYFLLLVLEMGIPEMNIGHLWEWADSLAMGLLIIKASSMEDRKGLGFLLAGLMTQRHLTAVHHGLIVFLTVALAVVGRSIYNGQKERKGLSFTIPLASLLGGPGSGLRMLALWECLGGRGRRSLSEPLTVVGVMLAMASGLLRHSSQEALLVLSAGSFLILMLILGTRRLQLTAEWAGLAEWNPELVNEGGEVSLKVRQDAMGNLHLTEVEREERRLALWLAFGLLASAFHWSGILVTMGAWTLYELFSSARRTDLVFSGQLSDHGEKRPFDIKDGVYRIYAPGLVWGHRQIGVGYGTKGVLHTMWHVTRGAALSVEGAVSGPYWADVREDVVCYGGAWSLEGKWGGEVVQVHAFPPDSGHKVHQCQPGKLNLEGGRVMGAIPIDLPRGTSGSPIINAQGVVLGLYGNGLKSNDVYISSIAQGSVEKSRPEMPLAIQGGRWTSKGSITVLDMHPGSGKTHRVLPELIRECIDKRLRTVVLAPTRVVLKEMERALQGKRVKFHSAAVDNTSSSLGAIVDVMCHATYVNRRLLPQGRQNWEVAIMDEAHWTDPHSIAARGHLYSLAKENRCAFVLMTATPPGKSEAFPESKGAIVSEERPIPDGEWRDGFDWITEFEGRTAWFVSSIAKGGAIARTLRQKGKSVICLNSKTFDKDYGRVREEKPDFVVTTDISEMGANLDVNRVIDGRTNIKPEEIDGRVELAGTRRVTTASAAQRRGRVGRHEGRTDTYVYSGQCDDDDSSLVQWKEAQILLDNITTVRGPVATFYGPEQGKMLEVAGHFRLTEEKRKHFRHLLTNCDFTPWLAWHVAANTTCVTDRKWTWEGPEENAIDGPDGELVTFRSPNGAERKLKPVWKDSRMFREGRDVADFLQYASGRRSAMDIFTGLGGVPDLLRLRCTAAWDVVYTLLNETPGSRAMKMAERDAPEAMLTLLEVAVLGIATLGVIWCFIVRTSVSRMVLGTVVLVVALILLWLGGMDYGTMAGVALIFYLLLTVLQPEPGKQRSGEDNRLAFLLIGLGSVIGLLAANELGYLERTKADIAGLFRHDTQGDRVWDTWTNIDIQPARSWGTYVFIVSLFTPYMLHQLQTKIQRLVNSSVAAGTQAMKDLGGGTPFFGVAGHVVALGVTSLVGATPTSLALGVALAILHLAVVTSGLEAELTQRAHRAFFSAMVKNPMVDGEVINPIPDGEPKPALYERKMSLLLAVGLCIAAVALNRTAAAMTEAGAVAVAALGQLLRPEEESWWTMPMACGMAGLVRGSLWGLLPVLHRIWLRTQGARRGGAEGSTLGDIWKQRLNSCTKEEFFAYRRTGVMETNRDQARELLRRGETNMGLAVSRGCAKLAWLEERGYATLKGEVVDLGCGRGGWSYYAASRPSVMAVKAYTIGGKGHEAPRLVTSLGWNLIKFRSGMDVFSMPATRVDTILCDIGESNPDPEKEGTRSRRVILLMEQWKARNPDAAAVFKVLAPYRPEVLEALHRFQLQWGGGLVRVPFSRNSTHEMYYSTAVTGNLVNSVNVLSRKLLARFGETRGPIQVPEIDLGTGTRCVTLAEDKVKPSDVMERIGALKEQYSESWHEDKEHPYRTWQYWGSYRTPATGSAASLINGVVKLLSWPWNAREDVTRMAMTDTTAFGQQRVFKEKVDTKAQEPQPGTRVIMRAVSDWLLEHLHSRARVRMCTRDEFIAKVRSNAALGAWSDEQNKWSSAKEAVEDPEFWNLVDEERSRHLKGQCRHCVYNMMGKREKKLGEFGVAKGSRAIWYMWLGSRFLEFEVLGFLNEEHWASRVVSGAGVEGTSLNYLGWLLRELGAKDGGRLYADDTAGWDTRITNADLEDEEQILRYMEGEHHVLAKTILEKAYHAKVVKVARPSPQGGCVMDVITRRDQRGSGQVVTYALNTITNMKVQLIRMMEGEGVIGPADSQDPRLERVEAWLKEHGAERLGRMLVSGDDCVVKPIDDRFGKALYFLNDMAKTRKDVGEWEPSVGFTDWEEVPFCSHHFHELVMKDGRSLIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLNYFHRRDLRTLGLAICSAVPVNWVPMGRTTWSIHASGEWMTTEDMLRIWNKVWILDNPHMENKQMVDEWRDIPYLPKTQDLVCSSLVGRKERAEWAKNIWGSVEKVRKLIGAEEYRDYLANMDRHDLHWELKLESSII","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0046983","name":"protein dimerization activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004252","name":"serine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0044423","name":"virion component","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003724","name":"RNA helicase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004386","name":"helicase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004482","name":"mRNA 5'-cap (guanine-N7-)-methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004483","name":"methyltransferase cap1 activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003968","name":"RNA-directed RNA polymerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0039694","name":"viral RNA genome replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005198","name":"structural molecule activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019028","name":"viral capsid","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016817","name":"hydrolase activity, acting on acid anhydrides","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0017111","name":"ribonucleoside triphosphate phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019058","name":"viral life cycle","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003725","name":"double-stranded RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016032","name":"viral process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016070","name":"RNA metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0032259","name":"methylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"d798a6f37980000b45969b8b3fddcd909e454b3b","counters":{"domain_architectures":338,"entries":84,"isoforms":0,"proteomes":0,"sets":10,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":12,"cdd":4,"pfam":16,"ssf":6,"profile":6,"smart":2,"pirsf":1,"ncbifam":1,"interpro":36},"proteome":0,"taxonomy":1,"similar_proteins":338}}}