{"metadata":{"accession":"A0A8D2MUT9","id":"A0A8D2MUT9_ZONAL","source_organism":{"taxId":"44394","scientificName":"Zonotrichia albicollis","fullName":"Zonotrichia albicollis (White-throated sparrow)"},"name":"Glutamate receptor","description":["Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells","Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system"],"length":1010,"sequence":"MEVLMLWLFPWIFQCVSVRADSIIHIGAIFEGNAAKDDEVFKQAVSDLNLNDDILQSEKITYSIKLIEANNPFHAVQEACDLMTLGILALVTSTGCASANALQSLTDAMHIPHLFVQRSTGGSPRTACQLNPSLEDEEYTLAARPPVRLNDVMLKLVTELRWQKFIVFYDSDYDIRGLQGFLDQASRLGLDVSLQKVDRNISRVFSNLFTTMKTEELNRYRDTLRRAILLLSPRGAQTFINEAVETNLASKDSHWVYVNEEITDNEILELVHSALGRMTVIRQIFPLARDNNQRCMRNNHRISSLLCDPQEGYLQMLQVSNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCMRKSTKPWNGGRSMLETIKKGHITGLTGVMEFREDGANPYVQFEILGTSYSETFGKDVRRLATWDSEKGLNGSLQERRLGNDLQGVTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKNLGFKYEIYQAPDGKYGHQLQNSSWNGMIGELINKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKINIFSLFAPFDFAVWACIAAAIPIVGVLIFVLNRIQAVRAQGAAQPSPSVSSTLHSAIWVVYGAFVQQGGESTVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQMDISYGTVRDSAVYEYFKAKGTNPLEQDNTFAELWRTISKNNGADNCVSNPSEGIRKAKKGNYAFLWDVTVVEYAALTDDECSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQESGDLDVLKQKWWPRMGRCDLNSHTNAQTDGKALKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLIDEDIAHKQISPASIEISALEIGGMQPAQTLEPVREYQNTQLSVSTFLPEQTTHGASRTLTAASGSNLPLPLSSSATMPSIQCKHRSPNGGLFRQSPVKTPIPMSFQSVPGGVIPEAMEPSHGTSI","proteome":"UP000694413","gene":"GRID1","go_terms":[{"identifier":"GO:0015276","name":"ligand-gated monoatomic ion channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005216","name":"monoatomic ion channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0038023","name":"signaling receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006811","name":"monoatomic ion transport","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5be5a75d8df7f532ccd193e3dc07978378ca7a85","counters":{"domain_architectures":33948,"entries":20,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":3,"cdd":2,"pfam":3,"smart":2,"panther":1,"prints":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":33948}}}