{"metadata":{"accession":"A0A8D2KE93","id":"A0A8D2KE93_UROPR","source_organism":{"taxId":"9999","scientificName":"Urocitellus parryii","fullName":"Urocitellus parryii (Arctic ground squirrel)"},"name":"DIS3-like exonuclease 2","description":["3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation"],"length":890,"sequence":"MSHPDYRLNLRPLGTPRGVSSVIGPHGFGASPGDKKSKNKSTRGKKRSIFETYMSKEAVSEGLKRGALIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEQWKVIKPESNDKETEAAYESDLPEELCGNHLPQQALKGYNDSPDVIIEAQFGDSDSEEGHGDTQNVLVDGVEKLSVRTQDKGKEDANAPVTKDESTSMSQDTKALSEKSLQKSAKVVYILEKKHSRAATGILKLLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQDFVTRPKDYANTLFICRIVDWKEDSNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQSLPWTIPPEELSKRRDLRKDCIFTIDPSTARDLDDALSCRPLADGTFEVGVHIADVSYFVPEGSHLDKVAADRATSVYLVQKVVPMLPRLLCEELCSLNPMTDKLTFSVIWTLTPEGKILKEWFGRTIIRSCTKLSYEHAQSMIESPSEKIPEEELPPISPEHSSEEVHQAVLNLHRIAKQLRQQRFVDGALRLDQLKLAFTLDSETGLPQGCHIYEYRDSNKLVEEFMLLANMAVAHKVYRAFPEQALLRRHPPPQMKMLNDLVEFCDQMGLSMDASSAGALNKSLTKIFGDDKYSLARKEVLTNMYSRPMQMALYFCSGVLQDQAQFRHYALNVPLYTHFTSPIRRFADVMVHRLLAAALGYREQPEVEPHALQKQADHCNDRRMASKRVQELSASLFFAVLVKESGPLESEAMVMGVLNQAFDVLVLRYGVQKRIYCNALALRSYHFQKVGKKPELTLIWEPKDPEQEPARQVRAPHIPSAPQVAVGPLLPPRCPLCPHLPPPSLALQAPGGASGLHAKAPATPRAQVAS","proteome":"UP000694417","gene":"DIS3L2","go_terms":[{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004540","name":"RNA nuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000175","name":"3'-5'-RNA exonuclease activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"85907db5b452707f679a7c0e15d34ba86372851e","counters":{"domain_architectures":1246,"entries":20,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":1,"pfam":4,"smart":1,"hamap":1,"panther":1,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":1246}}}