{"metadata":{"accession":"A0A8D2IKE1","id":"A0A8D2IKE1_UROPR","source_organism":{"taxId":"9999","scientificName":"Urocitellus parryii","fullName":"Urocitellus parryii (Arctic ground squirrel)"},"name":"Cell cycle checkpoint protein RAD17","description":["Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation. Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites. May also serve as a sensor of DNA replication progression"],"length":678,"sequence":"MSKTFLRPKVSSTKVIDWVDPAFDDFSENTVVSTAAPLGVNNSSHRRKYVPPALESSRFPARKRGKLFSSEQIFGLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAEVLERQSKQGGSILLITGPPGCGKTTTIKILSKEHGIQVQEWINPVLPDFQKDDFKDIFNFESNFHSFPYQSQIAVFREFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVQIGRCPLIFIISDSASGDNNHRLLFPKEIQEECSIANISFNPVAPTIMMKFLNRIVTIEANKNGGKIIVPNKTSLELLCQGCSGDIRSAINSLQFSSSKGESNLWPRKKGVSLKSDAALSKSKRVKKPDRVIENQEIQAIGGKDASLFLFRALGKILYCKRAPLTELDSPRLPSHLSEHERDTLLIQPEEVVEMSHMPGELFNLYLHQNYIDFFMEVDDLVRASEFLSFADVLSGDWNTRSLLREYSTSVATRGVMHSNKARGFAHCQGGGSSFRPLHKPQWFLIFKKYRENCMAAKALFSDFCLPALCLQTQLLPYLALLTIPMRNQAQISFIQDIGRLPLKQHFRRLKMEALMDREHGLIDPDTGNEAQLNGAQTTEENQGEPTQTAEPEILPLSQNSGSELPASQPQPFSSQVDMEEEDIIIEDYESDGT","proteome":"UP000694417","gene":"RAD17","go_terms":[{"identifier":"GO:0003689","name":"DNA clamp loader activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000077","name":"DNA damage checkpoint signaling","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0031389","name":"Rad17 RFC-like complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4b4062e3f9ca81c610feb7a18e9726e715fb5a9b","counters":{"domain_architectures":2806,"entries":9,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"cathgene3d":1,"ssf":1,"cdd":1,"ncbifam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":2806}}}