{"metadata":{"accession":"A0A8D2A181","id":"A0A8D2A181_PIG","source_organism":{"taxId":"9823","scientificName":"Sus scrofa","fullName":"Sus scrofa (Pig)"},"name":"Uroporphyrinogen-III synthase","description":["Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme)"],"length":297,"sequence":"MPAECFTCPASRCAKRRRSCSLRVPYKDGPATMKVLLLKDPKEDDDRGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEGYGGLIFTSPRAVEAVKLCLEKANKTEAWETSLKEKWNSKSVYVVGNATASLVSKIGLDPEGENCGNAEKLAEYICSRESSALPLLFPCGNLKRETLPRMLKDKGVPMESITVYQTIPHPGIQGNLNSYYSQQGIPASITFFSPSGLSYSLKHIQELSGDSIDQIKFVAIGPTTARALAAQGLPVSCTAESPTPRALAAGIRTALQPHRC","proteome":null,"gene":"UROS","go_terms":[{"identifier":"GO:0004852","name":"uroporphyrinogen-III synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0033014","name":"tetrapyrrole biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006780","name":"uroporphyrinogen III biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"8fb265d2a8e7629a163d36589a380c0cdac16a4f","counters":{"domain_architectures":23907,"entries":8,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cdd":1,"cathgene3d":1,"panther":1,"pfam":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":23907}}}