{"metadata":{"accession":"A0A8C8GNB2","id":"A0A8C8GNB2_ONCTS","source_organism":{"taxId":"74940","scientificName":"Oncorhynchus tshawytscha","fullName":"Oncorhynchus tshawytscha (Chinook salmon)"},"name":"Beta-secretase 1","description":["Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1"],"length":515,"sequence":"MIGRVTGRASRLLILGLHFGTNEAEVEPNTSGPLTLHFPLRQGPLSETQPPHVAPQRSSRAARRRRGVMGINFVDMIDNLRGKSGQGYYVEMAVGSPPQKLNILVDTGSSNFAVGAAAHPFLCRYYHRSLSNSYRDLGRSVYVPYTQGRWEGELGTDLVSVPHGPNASLRANIAAITQSDRFFINGSNWEGILGLAYAEIARPDEMLEPFFDSLVRQTPVPNLFSLQMCGAGFTQNYSLGSATVGGSMIIGGVDSSLYVGDLWYTPIRREWYYEVIIVRIEVNGQDLNMDCKEYNYDKSIVDSGTTNLRLPRKVFQAAVKAIEAASSTEQFPSGFWLGEQLVCWQAGTTPWHIFPVISLYLMSENRNQSFRISILPQQYLRPVEDVASAQEDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRQRKRIGFAVSTCHVHDEFRTASVEGPFHGVDLEDCGYNIPQTDESTLMTIAYIMAGICALFMLPLCLMLCQWRFSRCLRPSGAGDFADNISLLK","proteome":"UP000694402","gene":"BACE1","go_terms":[{"identifier":"GO:0004190","name":"aspartic-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4f7e38ba910b0f25f406cea3df5f8e462e02113f","counters":{"domain_architectures":46498,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cdd":1,"cathgene3d":1,"pfam":1,"profile":1,"panther":1,"prints":3,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":46498}}}